Most Accessed Article: Recent Advances in Site Specific Conjugations of Antibody Drug Conjugates (ADCs)
...
Wednesday, December 28, 2016
Wednesday, December 21, 2016
Wednesday, December 14, 2016
Podcast for (Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies)
Podcast for (Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies)
...
Thursday, December 8, 2016
Free Online Issue of Current Cancer Drug Targets
Free Online Issue of Current Cancer Drug Targets
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Tuesday, December 6, 2016
Issue Published Current Cancer Drug Targets Vol. 17 Issue 1
Issue Published Current Cancer Drug Targets Vol. 17 Issue 1
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Wednesday, November 30, 2016
Highlighted Article: Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia?
Highlighted Article: Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia?
...
Thursday, November 24, 2016
Tuesday, November 8, 2016
Call For Paper
Bentham Science Publishers would like to invite you to submit your research paper for publishing in the Journal of
Recent Patents on Current Cancer Drug Targets
...
Wednesday, November 2, 2016
Highlighted Article: Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening
Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening
Author(s):
Amit Sharma, Nidhi Jyotsana, Courteney K. Lai, Anuhar Chaturvedi, Razif Gabdoulline, Kerstin Görlich, Cecilia Murphy, Jan E. Blanchard, Arnold Ganser, Eric Brown, John A. Hassell, R. Keith Humphries, Michael Morgan and Michael Heuser ...
Monday, October 24, 2016
Most Cited Article: Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Cytochromes P450 and Skin Cancer:
Role of Local Endocrine Pathways
Author(s):
Andrzej T. Slominski, Michal A. Zmijewski, Igor Semak, Blazej
Zbytek, Alexander Pisarchik, Wei Li, Jordan Zjawiony and Robert C. TuckeyPages
77-96 (20)
Abstract:
Skin is the largest body organ forming a
metabolically active barrier between external and internal environments. The
metabolic barrier is composed of cytochromes P450 (CYPs) that regulate its
homeostasis...
Tuesday, October 18, 2016
Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer
Article Details
Advances in Synergistic Combinations of Chinese Herbal Medicine
for the Treatment of Cancer
Author(s):
Xue-Qing Hu, Yang Sun, Eric Lau,
Ming Zhao and Shi-Bing SuPages 346-356 (11)
Abstract:
The complex pathology of cancer development requires correspondingly complex
treatments. The traditional application of individual single-target drugs fails
to...
Monday, October 10, 2016
Indian Authors have made substantial contributions to Bentham Science Journal Current Cancer Drug Targets
Indian Authors have made substantial contributions to Bentham Science Journal Current Cancer Drug Targets
Journal Name: Current Cancer Drug Targets
Article Title: DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer
Author(s): Varinder Singh, Prince Sharma and Neena CapalashAbstract
DNA methylation is an epigenetic modification involved in gene expression regulation. In cancer, the DNA methylation pattern becomes aberrant,...
Tuesday, October 4, 2016
Podcast Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies
Podcast Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies
...
Open Access Plus Article in the journal Current Cancer Drug Targets
The article entitled ‘Pleiotropic Role of HSF1 in Neoplastic Transformation’ in the journal Current Cancer Drug Targets, 2014, 14, 144-155, is now open for all to view and access.
Abstract
Platycodin D (PD), a major saponin derived from Platycodin grandiflorum, exerted cytotoxicity against prostate cancer cell lines (PC3, DU145 and LNCaP cells) with IC50 values in the range of 11.17 to 26.13μmol/L, whereas RWPE-1cells (a...
Issue ::: Current Cancer Drug Targets, 16 Issue 7
Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.
Current Cancer Drug Targets publishes original research articles, letters, reviews, drug clinical trial studies and guest edited thematic issues...
Issue ::: Current Cancer Drug Targets
Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.
Current Cancer Drug Targets publishes original research articles, letters,...
Friday, August 12, 2016
Friday, June 24, 2016
Pleiotropic Role of HSF1 in Neoplastic Transformation
Author(s):
Natalia Vydra, Agnieszka Toma and Wieslawa WidlakPages 144-155 (12)
Abstract:
HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a probable reason...
Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo
Author(s):
Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia XuPages 860-871 (12)
Abstract:
Platycodin D (PD), a major saponin derived from Platycodin grandiflorum, exerted cytotoxicity against prostate cancer cell lines (PC3, DU145 and LNCaP cells) with IC50 values in the range of 11.17 to 26.13μmol/L, whereas RWPE-1cells...
Cancer Stem Cells in Solid and Liquid Tissues of Breast Cancer Patients: Characterization and Therapeutic Perspectives
Author(s):
Rena Chiotaki, Hara Polioudaki and Panayiotis A. TheodoropoulosPages 256-269 (14)
Abstract:
Breast cancer stem cells (BCSCs) represent a heterogeneous subpopulation of rare cells within breast cancer tumors, displaying an enhanced tumor initiating capability and underlying disease progression and therapy resistance. Unraveling their phenotypic, biological and...
A Comprehensive Outline of Trastuzumab Resistance Biomarkers in HER2 Overexpressing Breast Cancer
Author(s):
Otília Menyhart, Libero Santarpia and Balazs GyorffyPages 665-683 (19)
Abstract:
The introduction of trastuzumab for anti-HER2 therapy dramatically changed the clinical outcome for HER2 (ERBB2, neu) positive breast cancer patients. Today, patients eligible for trastuzumab are selected using HER2 expression/amplification status of the primary tumor. However, acquired...
Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer
Author(s):
Xue-Qing Hu, Yang Sun, Eric Lau, Ming Zhao and Shi-Bing SuPages 346-356 (11)
Abstract:
The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations...
